Course Directors

Claudio Fiorino, Physicist, Istituto Scientifico San Raffaele, Milano, (IT)
Giovanna Gagliardi, Physicist, Karolinska University Hospital, Stockholm (SE)

The aim of the course is to provide both basic information and an update on dose-volume response relationships in normal tissues and their application in the clinic. The course content embraces several disciplines. We have tried to represent the complexity of, and the interactions among the various fields. The teaching faculty therefore also includes radiobiologists, radiotherapists, and physicists. The course will start with a talk by a radiobiologist, which will illustrate the complexity of the issues. The input data used in models, i.e. dosimetrical and clinical data, the models themselves and the dosimetric predictors of normal tissue complications following radiotherapy will be presented in the first session. This will be followed by a review of the contemporary knowledge of dose-volume response relationships of the major organ sites, i.e. head and neck, thorax, abdomen and pelvis. The impact of dose-volume response relationships in treatment-planning optimisation and strategies for treatment customisation applied in the clinical routine will be presented. In the final session two issues of increasing relevance will be discussed: modelling in hypofractionation situations and the inclusion of genetic factors in the modelling of dose-volume response relationships.

The course is mainly aimed at radiation oncologists, physicists and dosimetrists actively involved in advanced planning optimisation with 3DCRT and IMRT.

Educational Programme

 

Introduction
9.00 – 9.10:        Introduction

                            

9.05 – 9.30:        Dose-volume modelling: a multidisciplinary approach

                            Michael BAUMANN

Methodological issues
 9.30- 10.00        Scoring toxicity: improving objectivity for precise dose-volume modeling

                            Giuseppe SANGUINETI

10.00- 10.30       Methodological aspects in dose-volume relationship studies

                            Tiziana RANCATI

10.30 - 11.00      Treatment planning evaluation: models and predictors

                            Ludvig MUREN

11.00 - 11.30      Coffee Break

 

Review of the knowledge on dose-volume relationships for the major organ sites
 11.30 - 12.00:   Head and neck

                            Avraham EISBRUCH
 12.00 - 12.30:   Thorax

                            Giovanna GAGLIARDI

 12.30 - 13.00:   Pelvis

                            Joos LEBESQUE

 13.00 - 14.00:   Lunch

Applications in planning optimisation and treatment customisation
 14.00 - 14.30:   Biological inverse optimization

                            Markus ALBER

 14.30 - 15.00:   Treatment customisation through NTCP modeling

                             Randall TEN HAKEN
 15.00 - 15.30:   Boosting intra-prostatic lesions: using NTCP for “safe” dose escalation with IGRT

                            Claudio FIORINO, Paola MANGILI,

                             Tiziana RANCATI   (presenting)

 15.30- 16.00:    Coffee break

Challenges
 16.00 - 16.30:   Considerations on hypofractionation

                            Alan NAHUM

 16.30 – 17.00:   Genetic mapping and dose-volume response relationships

                            Elisabeth TRAVIS

Summary